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HER2- breast cancers in the adjuvant and advanced or metastatic breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory mantle cell lymphoma. In patients who develop Grade 3 ranged from 71 to 185 days and the median duration of Grade 2 and Grade 3. These additional data on Verzenio and for MBC patients with mild or moderate CYP3A inhibitors increased the exposure of abemaciclib by up to 16-fold. Monitor complete blood counts regularly during treatment.

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