What makes us human is a question that not only science asks, but all disciplines of mind from philosophy to religion to sociology and ethics, and even to storytelling and the arts.
Tim Disney’s new movie “William” is about a Neanderthal living in the modern world and forces us to ask about humanness and many other questions.
Disney’s movie provides a foil to explore many facets of human nature and sociology, and raises questions about technology and its present and future effects on the human phenomenon.
With research interests and experience exploring the distinctions in the Neanderthal and Human genomes, Alysson Muotri, Director of the UC San Diego Stem Cell Program, brought together a panel of experts from across a spectrum of disciplines to explore these issues in a lively and engaging forum with the movie’s creator.
Watch — Neanderthal Among Us? Science Meets Fiction – A Discussion of Tim Disney’s Motion Picture “William”
Inside of each brain, there is the possibility to understand how trillions of neural connections come to sense the world, record memories, create an individual, and shape who you are and who you will become. Can we ever learn how this happens?
By using cortical organoids – self organized clusters of neurons generated by stem cells, that is what Alysson Muotri’s lab at the Sanford Consortium for regenerative medicine wants to learn.
Called “brain organoids” because they exhibit many of the characteristics of a developing brain they are asking what happens to build a brain? What happens to create a human mind, and who we are? How does this process become disordered, giving rise to conditions like autism, schizophrenia, epilepsy, and degeneration? And how can they find ways to intervene and rescue the mind from disorders, and even restore lost function?
Muotri’s lab and a host of collaborators in and out of UC San Diego are using a diverse array of methods and tools on these brain organoids, from researching the details of vision to how neurons connect and form networks, to engineering ways to help the organoids become more complex, to the differences between normal brains and brains with cognitive disorders, even to growing brain organoids in space to understand causes of autism and Alzheimer’s disease.
Join Alysson Muotri, Director of the UC San Diego Stem Cell Program as he takes you on a journey to visit the labs and collaborators who are exploring how a brain is built on Building the Brain.
Watch — Building The Brain With Alysson Muotri
“All the best models are the ones that you can improve in complexity to get closer and closer to the reality.”
The idea of a brain in a dish may sound like science fiction to some but scientists are becoming more and more adept at creating cortical organoids in the lab. The organoids are models of what is happening in utero as the brain forms. Being able to study this kind of human development not only opens new insights into neurological conditions but raises ethical questions.
Alysson Muotri, director of the UC San Diego Stem Cell Program, gives a look at how his lab is using these organoids to model specific conditions, treat disease, and explore fundamental brain mechanisms. Learn what the limitations, future projections, and ethical concerns are surrounding this exciting science.
Watch Re-constructing Brains in the Lab to Revolutionize Neuroscience – Exploring Ethics